What Is Semaglutide Injection?- What You Need To Know

what is semaglutide

The never-ending quest for effective and safe weight loss treatments continues, but the latest anti-obesity medication, semaglutide, is still causing a stir over a year after being approved by the U.S. Food and Drug Administration in 2021.

Semaglutide, an injectable drug used for diabetes, is the first medication since Saxenda in 2014 to receive approval for managing chronic weight in the 70% of American adults who are overweight or obese. Ongoing research consistently demonstrates the effectiveness of semaglutide injections for weight loss. Additionally, it emphasizes the importance of treating obesity as a chronic metabolic disease. But, it’s important to note that semaglutide is not a miracle drug, and it is not suitable for everyone.

Now, let’s delve into what you need to know about semaglutide.

What is Semaglutide?

Semaglutide is categorized as a glucagon-like peptide-1 receptor agonist (GLP-1 RA) medication. It imitates the GLP-1 hormone, which is released in the digestive system after eating.

GLP-1 has various functions, one of which is stimulating the body to produce more insulin to lower blood sugar levels. This has led healthcare providers to use semaglutide for over 15 years in the treatment of Type 2 diabetes.

But, GLP-1 also has an impact on the brain regions that regulate appetite and satiety. When combined with diet and exercise, it can lead to significant weight loss. It can also reduce the likelihood of developing cancer, and heart disease in individuals who are overweight or obese.

Semaglutide injections for weight loss

Semaglutide, marketed as Wegovy for weight loss, is currently the only approved brand for this purpose. The recommended dosage for weight loss is 2.4 milligrams per week, administered through self-injections under the skin.

But, due to the increasing interest in semaglutide for weight loss, healthcare professionals are exploring ways to meet the demand. Some doctors prescribe alternative brands of semaglutide like Ozempic and Rybelsus, which are FDA-approved for different uses, in an off-label manner.

According to Dr. Surampudi, many individuals use semaglutide off-label to manage weight, causing a shortage of medication for those who need it to control their diabetes.

How effective is semaglutide for weight loss in non-diabetics?

Many medications have been developed to combat obesity. But, semaglutide stands out as an exceptional option.

An initial study involving 2,000 obese adults compared the effects of semaglutide combined with a diet and exercise regimen to those of individuals who made similar lifestyle changes without using semaglutide. After 68 weeks, half of the participants taking semaglutide achieved a 15% reduction in body weight, and almost one-third experienced a 20% decrease. On the other hand, participants who relied on lifestyle modifications only lost about 2.4% of their weight.

Subsequent studies have replicated these findings, indicating consistent results. But, these studies have also revealed that individuals tend to regain the weight they lost once they discontinue the use of semaglutide.

Dr. Surampudi emphasizes that while dietary and exercise modifications remain the primary foundations for managing obesity, anti-obesity medications serve as an additional tool in the treatment plan, depending on the individual’s medical history.

What are the side effects of semaglutide injections?

The adverse reactions of semaglutide are generally not severe, especially when compared to the complications related to being overweight or obese.

Individuals using semaglutide for weight loss might encounter the following:

  • Feeling lightheaded
  • Fatigue
  • Digestive problems like diarrhea, constipation, and excessive gas
  • Headaches
  • Stomach-related issues such as nausea, vomiting, pain, or bloating

Among those who have recently begun taking semaglutide, gastrointestinal problems are the most reported issue. But, you may reduce these side effects by commencing with a lower dosage and increasing it.

The Importance of Lifestyle Changes

While semaglutide can aid in weight loss, it should be seen as a complement to lifestyle changes rather than a standalone solution. Adopting a balanced diet, engaging in regular physical activity, and making sustainable lifestyle adjustments remain crucial components of achieving long-term weight management success.

Benefits of Semaglutide for Weight Loss

Significant Weight Reduction: Semaglutide has been found to lead to substantial weight loss, surpassing the results achieved with other weight loss medications.

Improved Metabolic Health: Semaglutide not only aids in weight loss but also improves metabolic health parameters.

Sustained Weight Loss: Unlike some weight loss methods that result in weight regain, semaglutide has shown potential for sustained weight loss.

Is Semaglutide Right for You?

Semaglutide can be an effective option for individuals struggling with obesity. But, it is essential to consult with a healthcare professional to determine if it is the right choice for you. Your doctor will check your health, medical history, and weight loss goals to determine if semaglutide is suitable and safe in your specific case.

It is worth noting that semaglutide is not a standalone solution for weight loss. It should be used as part of a comprehensive weight management plan that includes a healthy diet, regular exercise, and lifestyle modifications. By combining semaglutide with these lifestyle changes, you can maximize the benefits and increase your chances of long-term weight loss success.

Read More : Where Can I Get Semaglutide For Weight Loss?


Semaglutide holds promise as an effective tool for weight loss. Its ability to reduce appetite, increase feelings of fullness, and improve metabolic health make it an attractive option for individuals struggling with obesity. With the right approach, semaglutide may be a valuable tool in the journey towards achieving a healthier weight and improving overall well-being.