Dr. Benjamin H. Krasne, M.D.
Board-certified physicianBoard-certified in anesthesiology, he reads medications and metabolism with a pharmacologist's eye, which shapes how he doses weight loss and longevity care.
Raise your own testosterone
Enclomiphene online for low testosterone in men
Enclomiphene is an oral medicine that prompts your body to make more of its own testosterone instead of replacing it, which helps preserve sperm production. A licensed clinician decides if it suits you. The price is $115 a month.
- Designed to help preserve sperm production
- Oral capsule, $115 a month
- Follow-up labs to track levels
Free to book. You pay only if you go ahead with treatment.
$115per month
Licensed U.S. clinician review
Form: Oral capsule, compounded
$115/motransparent price
5–10 minphone or video
No insuranceneeded
LicensedU.S. clinicians
Why get enclomiphene through My IV Doctors
Lab-confirmed diagnosis
Your clinician orders labs to confirm the type of low testosterone, since enclomiphene only works when your testes can still respond.
Fertility stays in focus
If you want children now or later, your clinician weighs enclomiphene against TRT, which commonly suppresses sperm production.
Straight talk on status
We explain that compounded enclomiphene is not FDA-approved and that long-term data are limited, so you can make an informed choice.
Ongoing dose adjustments
Follow-up blood tests show how your levels respond, and your clinician adjusts the plan or suggests another option if needed.
How to get enclomiphene online
- 1
Pick a time for your free visit
Choose phone or video. The first visit costs nothing, and insurance isn't required.
- 2
Talk with a clinician
In about 5–10 minutes, a licensed clinician reviews your symptoms, fertility plans and medicines, and orders morning blood tests such as testosterone, LH, FSH and estradiol if needed.
- 3
Start enclomiphene
If your results fit and enclomiphene suits you, it is prescribed and prepared by a licensed U.S. compounding pharmacy, with instructions on how to take it.
- 4
Recheck labs and adjust
Follow-up blood tests a few weeks after starting show how your testosterone and estradiol are responding, and the dose or schedule is adjusted from there.
Who enclomiphene is for
Low testosterone with low or normal LH
Lab work suggests the testes are under-signaled rather than failing, which is the situation enclomiphene is designed for.
Want children now or later
You want to raise testosterone without the sperm suppression that usually comes with testosterone therapy.
Prefer a daily pill
You would rather take an oral capsule than inject testosterone or apply a gel.
Not for testicular failure
If LH and FSH are already high because the testes themselves are not responding, enclomiphene is unlikely to help.
Not for clots, liver disease or certain tumors
A history of blood clots, active liver disease or a pituitary or other hormone-sensitive tumor needs specialist care rather than enclomiphene online.
Enclomiphene vs. testosterone replacement therapy
| Feature | Enclomiphene | TRT |
|---|---|---|
| Source of testosterone | Your own testes | Supplied from outside |
| Sperm production | Designed to be maintained | Commonly suppressed |
| Form | Oral capsule | Injections, gels and other forms |
| FDA status | Compounded, not FDA-approved | FDA-approved for diagnosed hypogonadism |
| Best suited to | Secondary hypogonadism | Testicular failure or when fertility isn't a goal |
What is enclomiphene?
Your testes make testosterone and sperm in response to two pituitary hormones, LH and FSH. The brain adjusts those signals partly by sensing estrogen. Enclomiphene is a selective estrogen receptor modulator that blocks that estrogen signal in the brain, so the pituitary releases more LH and FSH and the testes are prompted to make more testosterone themselves.
That is the opposite of what happens with testosterone replacement therapy. Added testosterone tells the brain to turn LH and FSH down, which can sharply lower sperm counts. Because enclomiphene keeps those signals running, it is mainly considered for men with secondary hypogonadism, where the testes work but are not getting enough signal, especially when fertility matters.
Enclomiphene is not FDA-approved as a standalone medicine. It is one of the two forms (isomers) that together make up clomiphene citrate, which is FDA-approved to induce ovulation in women. Enclomiphene for men comes from licensed U.S. compounding pharmacies, and compounded medicines are not FDA-approved. In 2022, an FDA advisory committee voted against adding enclomiphene to the 503A bulks list, the list of bulk drug substances pharmacies may use in compounding, citing limited clinical evidence. Your clinician will explain this and how it weighs against other options.
Enclomiphene vs. TRT
Both aim to relieve symptoms of low testosterone, but they get there differently and suit different men.
- Source of testosterone: enclomiphene boosts your own production; TRT supplies testosterone from outside.
- Fertility: enclomiphene is designed to maintain sperm production; TRT commonly suppresses it.
- Testicular size: TRT can shrink the testes; enclomiphene keeps them stimulated.
- Regulatory status: testosterone products are FDA-approved for diagnosed hypogonadism; compounded enclomiphene is not FDA-approved.
- Who it works for: enclomiphene needs testes that can respond. Men with testicular failure usually need TRT instead.
How fast enclomiphene works
Enclomiphene is taken by mouth, usually once a day or on a schedule your clinician sets. Testosterone levels typically rise over the first several weeks, which is why follow-up labs are timed a few weeks in. How much you feel depends on how low you started and whether other factors, such as sleep or weight, are also involved.
Studies, mostly short and modest in size, have shown that enclomiphene can raise testosterone into the normal range while keeping sperm counts closer to baseline than testosterone gel. Longer-term data are limited. If your levels or symptoms do not improve, your clinician may adjust the plan or suggest another option.
Enclomiphene side effects and safety
Enclomiphene is generally well tolerated in studies, but it is a hormone-active medicine with a limited long-term record. Regular labs keep it on track.
- Possible side effects include headache, hot flashes, nausea, mood changes and breast tenderness, usually mild.
- Stop taking it and contact your clinician right away if you notice blurred vision, spots, flashes or other visual changes, which have been reported with clomiphene.
- Raising testosterone also raises estradiol in some men. Your clinician checks estradiol and other labs and adjusts the dose if needed.
- Medicines of this class have been linked to blood clots; seek urgent care for leg swelling or pain, chest pain or sudden shortness of breath.
- Enclomiphene is compounded and not FDA-approved, so its quality depends on the compounding pharmacy; only use product from a licensed pharmacy on a prescription.
- Tell your clinician about every medicine and supplement you take, and do not combine enclomiphene with testosterone or other hormone products unless your clinician directs it.
Physicians who oversee your care
Independently licensed U.S. physicians supervise every treatment we offer.
Dr. Johnathan Chance Miller, M.D.
PhysicianTrained at Columbia and Washington University, he pairs prescriptions with practical habits around food, training and sleep.
Dr. Vanessa Niles, R.N., M.D., F.A.C.O.G.
OB-GYN, board certifiedAn OB-GYN for more than 40 years and a Fellow of ACOG, she leads women's health care, from perimenopause to PCOS.
Enclomiphene FAQs
Still deciding? The first consultation is free and takes about 5–10 minutes.
Book a free consultationWhat is enclomiphene?
Enclomiphene is a selective estrogen receptor modulator taken by mouth. It blocks estrogen feedback in the brain, which raises LH and FSH and prompts the testes to make more of their own testosterone.
Does enclomiphene have FDA approval?
No. Enclomiphene is not FDA-approved as a standalone medicine. It is a component of clomiphene citrate, which is approved for ovulation induction in women, and the enclomiphene prescribed for men is compounded, which is also not FDA-approved.
How much does enclomiphene cost without insurance?
Enclomiphene is $115 a month. The first visit costs nothing, and insurance isn't required.
Does enclomiphene affect sperm count and fertility?
It is designed to keep sperm production going by maintaining LH and FSH, unlike testosterone therapy, which often lowers sperm counts. Results vary, so men actively trying to conceive should also have their semen quality checked.
Enclomiphene vs. clomiphene: what's the difference?
Clomiphene is a mix of two isomers, enclomiphene and zuclomiphene. Enclomiphene is the part thought to drive the rise in testosterone, while zuclomiphene lingers longer in the body and has more estrogen-like activity.
How long does enclomiphene take to raise testosterone?
Levels usually rise over the first several weeks. Your clinician will order follow-up labs a few weeks after you start to see how you are responding.
Do I need blood work for enclomiphene?
Yes. Morning testosterone, LH and FSH help show whether enclomiphene is likely to work, and follow-up labs, including estradiol, guide dose changes.
Can I take enclomiphene instead of TRT?
For men whose testes still respond to LH and FSH, it can be an alternative, especially when fertility matters. Men with testicular failure usually need testosterone replacement instead.
Can I switch from TRT to enclomiphene?
Some men do, often to restore their own production. Your clinician will plan the timing and labs, because it can take time for natural signaling to recover after stopping testosterone.
Is enclomiphene a controlled substance?
No. Unlike testosterone, enclomiphene is not a federally controlled substance, though it still requires a prescription.
What are the side effects of enclomiphene?
Headache, hot flashes, nausea, mood changes and breast tenderness are reported most often, usually mild. Any change in vision needs prompt attention.
Why did an FDA committee vote against compounding enclomiphene?
In 2022, committee members cited limited clinical evidence of effectiveness when voting against adding enclomiphene to the 503A bulks list, which governs which bulk substances pharmacies may use in compounding. Your clinician can discuss what that means for you and what alternatives exist.
What if enclomiphene does not work for me?
Your clinician will review your labs and symptoms and may suggest a different dose, testosterone therapy or a referral to an endocrinologist or urologist.
Start enclomiphene with a free consultation
Book a free 5–10 minute phone or video visit. A licensed clinician reviews your symptoms and labs, and if appropriate prescribes enclomiphene for $115 a month.
Related treatments
References
- FDA: Pharmacy Compounding Advisory Committee meeting minutes, June 2022 (enclomiphene citrate)
- MedlinePlus: Clomiphene drug information
- Enclomiphene citrate: a treatment that maintains fertility in men with secondary hypogonadism (PubMed)
Medically reviewed October 2026. This page is general information and not a substitute for advice from your own clinician. Read our editorial policy.
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