Dr. Benjamin H. Krasne, M.D.
Board-certified physicianBoard-certified in anesthesiology, he reads medications and metabolism with a pharmacologist's eye, which shapes how he doses weight loss and longevity care.
Your own growth hormone, gently prompted
Sermorelin prescription online, guided by your labs
Sermorelin is a short peptide that nudges your pituitary gland to release more of your own growth hormone. A licensed clinician reviews your history and bloodwork first, and if it fits, compounded sermorelin ships to your door with everything you need for nightly injections.
- Free 5–10 minute consultation
- $175 for the first month
- IGF-1 labs guide every dose
Start with your state
Pick your state to see local rules, pricing and booking.
Select a state to start
Licensed U.S. cliniciansPrivate and HIPAA secureFree to book
Ready now? Book a free consultation. Free to book. You pay only if you go ahead with treatment.
$175first month
Licensed U.S. clinician review
Visit: Phone or video, 5–10 minutes
$175 first monthtransparent price
5–10 minphone or video
No insuranceneeded
LicensedU.S. clinicians
How the signal travels
Sermorelin works upstream of growth hormone
It doesn’t add growth hormone. It reminds the pituitary to release its own, and the body’s natural brake keeps that release in check.
- 01SermorelinA nightly shot of the GHRH signal, under the skin
- 02Pituitary glandAnswers with pulses of your own growth hormone, mostly during sleep
- 03Growth hormoneTravels through the blood to the liver and other tissues
- 04IGF-1Made by the liver; the lab number that shows your response
The built-in brake: as IGF-1 rises, the body releases somatostatin and the pituitary eases off. That feedback is why sermorelin’s effect is gentler than injecting growth hormone itself.
Why start sermorelin with My IV Doctors
Labs before and after
Baseline and follow-up IGF-1, thyroid and blood sugar checks mean your dose is set by measurable results instead of trial and error.
Clear first-month price
The first month is $175, the first visit is free and you never need insurance. Later costs are confirmed with you before refills.
Everything shipped cold
A licensed U.S. compounding pharmacy sends sermorelin with cold packs, mixing supplies, syringes and illustrated instructions.
A clinician who adjusts
Report side effects or changes anytime. Your clinician can raise, lower or stop the dose as your labs and symptoms evolve.
Getting sermorelin online, step by step
- 1
Pick a time for your free visit
Book a 5–10 minute phone or video visit and share your goals, health history and current medicines. There is no charge for this first conversation.
- 2
Get baseline labs
Your clinician orders or reviews bloodwork such as IGF-1, thyroid tests and blood sugar so there is a starting point to measure against.
- 3
Start nightly injections
If sermorelin fits, a licensed U.S. compounding pharmacy ships it cold with supplies and step-by-step mixing and injection instructions.
- 4
Check in and recheck IGF-1
After the first weeks you report how you feel and any side effects, and repeat labs show whether the dose should go up, down or stay put.
Who sermorelin can suit
Adults noticing midlife changes
People in their 30s, 40s and beyond who are working on sleep, recovery and body composition and want to discuss a growth hormone–related option with a clinician.
People open to a lab-first approach
You are willing to get baseline bloodwork, including IGF-1 and thyroid tests, and repeat it so dosing is based on numbers rather than guesswork.
Comfortable with a small nightly shot
Sermorelin is injected just under the skin with a fine insulin-style needle, usually at bedtime. Your clinician walks you through mixing and injecting.
Men and women alike
Both men and women can be candidates. Your clinician sets the dose around your sex, age, hormones, other medicines and how your labs respond.
When it is not a fit
It is usually avoided during pregnancy or breastfeeding, with active cancer or a recent cancer history, and in people who react to the drug or its ingredients.
Sermorelin vs. growth hormone vs. lifestyle alone
| Option | How it works | FDA status | Lab monitoring |
|---|---|---|---|
| Sermorelin (compounded) | Prompts your pituitary to release its own growth hormone | Compounded, not FDA-approved | IGF-1, thyroid and blood sugar |
| Prescription growth hormone | Supplies growth hormone directly | Approved for diagnosed deficiency and select conditions | Close specialist monitoring |
| Sleep, strength training and protein | Supports natural growth hormone release | — | Optional |
Sermorelin, explained
Your hypothalamus sends a hormone called growth hormone–releasing hormone (GHRH) to the pituitary gland, which answers with pulses of growth hormone, mostly during deep sleep. Sermorelin is a lab-made copy of the first 29 amino acids of GHRH, the part that does the signaling. It works upstream: instead of supplying growth hormone directly, it asks the pituitary to make more of its own.
That difference matters. Because the pituitary still responds to the body's own brakes, such as somatostatin and rising IGF-1, growth hormone release stays pulsed and self-limited rather than flooding the system. Growth hormone then prompts the liver to make IGF-1, the marker your clinician uses to see how you are responding.
Sermorelin was once sold as the brand-name drug Geref, approved in the 1990s to test pituitary function and to treat certain children with growth hormone deficiency. The maker stopped producing it in 2008 for business reasons rather than safety concerns. Today it is prepared by licensed compounding pharmacies and prescribed off-label for adults. The FDA does not review compounded drugs, and sermorelin is not FDA-approved for weight loss, sleep, body makeup or anti-aging use.
How sermorelin is taken
Sermorelin usually arrives as a freeze-dried powder that you mix with sterile water before use. Once mixed, it goes in the refrigerator. The original label called for one injection under the skin each night at bedtime, when the body's natural growth hormone pulse is strongest, and many clinicians still follow that timing.
Your clinician picks the starting dose and tells you how to adjust it. Injecting on an empty stomach, a couple of hours after your last meal, may help, because food and high blood sugar can blunt growth hormone release. Rotate injection sites around the belly or thighs to keep the skin comfortable.
- Mix the powder gently; don't shake the vial.
- Keep mixed vials refrigerated and protected from light.
- Use a fresh needle every time and a sharps container for disposal.
- Don't use a vial if the liquid looks cloudy or has particles.
What progress looks like
Sermorelin works gradually because it relies on your own pituitary. Some people notice better sleep within a few weeks; changes in energy, recovery or body composition, when they happen, tend to take months and depend heavily on exercise, protein intake and sleep habits.
Evidence in adults is still limited, and results vary from person to person. That is why lab checks matter: IGF-1 shows whether your body is responding at all, and your clinician uses it alongside how you feel to decide whether continuing makes sense.
Sermorelin compared with growth hormone injections
Prescription growth hormone (somatropin) replaces the hormone directly and is FDA-approved for diagnosed growth hormone deficiency and a few other conditions. It is expensive and its dose isn't limited by the body's feedback system.
Sermorelin instead stimulates your own production, so the body's feedback loops stay in charge. That generally means a gentler effect and a lower cost, but it also means it can't help if the pituitary itself can't make growth hormone.
Sermorelin side effects and safety
In the trials behind the original product, the most common problem was a reaction where the shot went in, seen in roughly one in six people. Other effects were uncommon. Because a small share of patients developed an underactive thyroid in those studies, thyroid levels are checked before and during treatment.
- Redness, swelling or soreness at the injection site, usually mild and short-lived.
- Less often: headache, flushing, dizziness, unusual sleepiness or restlessness, trouble swallowing or hives.
- Thyroid levels can drop; your clinician checks thyroid tests at the start and along the way.
- Steroid medicines such as prednisone can weaken the response, so list everything you take.
- Not used during pregnancy or breastfeeding, and generally avoided with active cancer.
- Get urgent care for signs of a serious allergic reaction, such as swelling of the face or trouble breathing.
Physicians who oversee your care
Independently licensed U.S. physicians supervise every treatment we offer.
Dr. Johnathan Chance Miller, M.D.
PhysicianTrained at Columbia and Washington University, he pairs prescriptions with practical habits around food, training and sleep.
Dr. Vanessa Niles, R.N., M.D., F.A.C.O.G.
OB-GYN, board certifiedAn OB-GYN for more than 40 years and a Fellow of ACOG, she leads women's health care, from perimenopause to PCOS.
Your first 90 days on sermorelin
A typical path. Your clinician adjusts the timing to your labs and how you feel.
- Day 0Free visit and baseline labsGoals, history and medicines reviewed; IGF-1, thyroid and blood sugar checked.
- Week 1First nightly injectionsSermorelin arrives cold with supplies. You mix, inject at bedtime and note how you sleep.
- Weeks 4–6Check-inReport side effects and changes. The clinician fine-tunes timing or dose if needed.
- Month 3IGF-1 recheckRepeat labs show whether your body is responding and guide the plan from here.
Sermorelin by state
See how online visits, labs and cold-chain shipping work where you live. Tap your state to start.
All states A–Z
- AL Alabama
- AK Alaska
- AZ Arizona
- AR Arkansas
- CA California
- CO Colorado
- CT Connecticut
- DE Delaware
- FL Florida
- GA Georgia
- HI Hawaii
- ID Idaho
- IL Illinois
- IN Indiana
- IA Iowa
- KS Kansas
- KY Kentucky
- LA Louisiana
- ME Maine
- MD Maryland
- MA Massachusetts
- MI Michigan
- MN Minnesota
- MS Mississippi
- MO Missouri
- MT Montana
- NE Nebraska
- NV Nevada
- NH New Hampshire
- NJ New Jersey
- NM New Mexico
- NY New York
- NC North Carolina
- ND North Dakota
- OH Ohio
- OK Oklahoma
- OR Oregon
- PA Pennsylvania
- RI Rhode Island
- SC South Carolina
- SD South Dakota
- TN Tennessee
- TX Texas
- UT Utah
- VT Vermont
- VA Virginia
- WA Washington
- WV West Virginia
- WI Wisconsin
- WY Wyoming
Sermorelin: your questions
Still deciding? The first consultation is free and takes about 5–10 minutes.
Book a free consultationWhat does sermorelin actually do?
It acts like the body's own growth hormone–releasing hormone, prompting the pituitary gland to release more growth hormone in natural pulses. Growth hormone then signals the liver to make IGF-1, which is what your clinician tracks in your labs.
Is sermorelin the same as HGH?
No. HGH, or somatropin, is growth hormone itself. Sermorelin is a signal that asks your pituitary to make more of its own growth hormone, so the body's natural brakes still apply.
Does sermorelin have FDA approval?
Not today. The brand-name version, Geref, was approved for children and was discontinued by its maker in 2008 for business reasons. Current sermorelin is compounded by licensed pharmacies and is not FDA-approved for weight loss, sleep, body makeup or anti-aging use.
How much does sermorelin cost here?
The first month is $175, and the first consultation is free with no insurance needed. Your clinician confirms the cost of later months and any lab fees before you continue.
How quickly does sermorelin work?
It is gradual. Some people sleep better within a few weeks, while changes in energy or body composition, if they come, usually take several months. Repeat IGF-1 labs show whether your body is responding.
When should I inject sermorelin?
Most people inject at bedtime, the timing used on the original label, because the body's largest natural growth hormone pulse comes during early sleep. Your clinician may suggest injecting a couple of hours after your last meal.
Can women take sermorelin?
Yes, women can be candidates. The clinician tailors the dose to your age, hormonal stage, medicines and lab results, and it is not used during pregnancy or breastfeeding.
What labs are needed for sermorelin?
Typically IGF-1, thyroid tests and a blood sugar marker such as A1C or fasting glucose, both at the start and again after you have been on treatment for a while.
What are the side effects of sermorelin?
The most common is a reaction at the injection site, such as redness or soreness. Less common effects include headache, flushing, dizziness, sleepiness or restlessness. Thyroid levels can drop, which is why they are monitored.
Who should not take sermorelin?
It is generally avoided during pregnancy or breastfeeding, with active cancer or a recent cancer history and in anyone allergic to it. Your clinician also reviews thyroid disease, diabetes and steroid use before prescribing.
How is sermorelin stored?
Keep it refrigerated once mixed and away from light. It ships with cold packs, so put it in the fridge when it arrives and follow the storage instructions in the package.
Can I take sermorelin with testosterone or other treatments?
Often, yes, but it depends on your full plan. Tell your clinician about every medicine and supplement, including testosterone, thyroid medicine and steroids, so the combination is reviewed first.
What happens if I stop sermorelin?
Because it stimulates your own production rather than replacing it, stopping simply lets your growth hormone release return to its previous pattern over time. Talk with your clinician before you stop so labs can be timed sensibly.
Start sermorelin with a free consultation
Book a free 5–10 minute phone or video visit. If a licensed clinician decides sermorelin fits, your first month is $175, shipped cold with supplies.
More healthy-aging options
References
- Mayo Clinic: Sermorelin (injection route)
- RxList: Sermorelin acetate (Geref) prescribing information
- Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? (PubMed)
- FDA: Compounding and the FDA, questions and answers
Medically reviewed October 2026. This page is general information and not a substitute for advice from your own clinician. Read our editorial policy.
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