
Dr. Benjamin H. Krasne, M.D.
Board-certified physicianBoard-certified in anesthesiology, he reads medications and metabolism with a pharmacologist's eye, which shapes how he doses weight loss and longevity care.
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Private care for desire and comfort
Low desire, slower arousal or sex that has started to hurt are common and treatable, and you can talk about them privately. A licensed clinician listens, looks for causes such as medicines or hormone changes, and walks you through prescription options that fit your stage of life.
Free to book. You pay only if you go ahead with treatment.
Talk by phone or video from wherever you feel comfortable, with a clinician who treats these concerns as routine medical care.
Medicines, mood, hormones and other conditions are considered first, so treatment targets what is actually driving the change.
Addyi, Vyleesi and vaginal estrogen are all on the table, along with clearly labeled compounded choices like PT-141 and oxytocin.
Plans start from $99 a month, the first visit is free and medicines arrive in plain packaging with no clinic label.
Choose phone or video. In about 5–10 minutes, share what has changed, your cycle or menopause stage and the medicines you take.
Your clinician considers medicines, mood, relationship stress, hormones and other conditions, and may suggest labs such as thyroid tests.
Options range from Addyi or Vyleesi for low desire to vaginal estrogen for dryness, or compounded PT-141 or oxytocin.
Check in after several weeks. If a treatment isn't helping, your clinician changes the plan or stops it.
You used to want sex more and the change bothers you, whether it came on slowly or after a life event, a new medicine or a hormonal shift.
Your interest is there, but your body is slower to respond, or reaching orgasm has become harder than it used to be.
Dryness, burning or pain with intimacy have started during perimenopause or after your periods stopped.
You suspect an antidepressant, birth control or another prescription is affecting your libido and want to talk about alternatives.
New bleeding, pelvic pain that isn't tied to sex or a possible infection need an in-person exam, and your clinician will point you there.
| Option | How it's used | Main purpose | FDA status |
|---|---|---|---|
| Addyi (flibanserin) | Pill every night at bedtime | Low desire (HSDD) | Approved for women under 65 |
| Vyleesi (bremelanotide) | Shot at least 45 minutes before sex | Low desire (HSDD) | Approved before menopause |
| Vaginal estrogen | Cream, tablet or ring in the vagina | Dryness and painful sex after menopause | Approved |
| PT-141 troche or oxytocin spray | Dissolves in the mouth or nasal spray | Desire and closeness | Compounded, not FDA-approved |
Desire and arousal depend on many things at once: hormones, mood, stress, sleep, relationships, medical conditions and the medicines you take. Antidepressants, some blood pressure medicines and birth control can all play a part. So can perimenopause and menopause, when falling estrogen can make vaginal tissue thinner and drier and turn sex uncomfortable.
When low desire causes you distress and isn't better explained by another condition, medication or a relationship problem, clinicians call it hypoactive sexual desire disorder, or HSDD. Two FDA-approved medicines treat it: Addyi, a pill taken at bedtime, and Vyleesi, a shot used as needed. Painful sex after menopause has its own approved treatments, including low-dose vaginal estrogen.
Not every option is a pill for desire. Sometimes the most useful step is changing a medicine that dampens libido, treating vaginal dryness or checking thyroid and other labs. Your clinician helps you sort out which pieces apply to you and refers you for in-person care, such as pelvic floor therapy or counseling, when that would help more.
Addyi (flibanserin) is a pill taken once a day at bedtime. It was first approved in 2015 for premenopausal women, and in December 2025 the FDA expanded its label to women younger than 65, which includes many women after menopause. It works on brain chemicals tied to desire and can take several weeks to show an effect; if nothing has improved after about eight weeks, it is usually stopped.
Vyleesi (bremelanotide) is a small shot you give yourself in the thigh or belly at least 45 minutes before sex. It is approved for premenopausal women with HSDD, used no more than once in 24 hours and no more than eight times a month. PT-141 troches, a compounded version of the same molecule, dissolve in the mouth instead; compounded medicines are not FDA-approved.
Low-dose vaginal estrogen, as a cream, tablet or ring, treats the thinning and dryness that often follow menopause. Very little reaches the bloodstream, and it is FDA-approved for this purpose. Many women notice more comfort within a few weeks, with full benefit after a few months.
Vaginal moisturizers used a few times a week and lubricants used during sex help too, either alone or alongside a prescription. If pain continues, your clinician may suggest pelvic floor physical therapy or an in-person exam to look for other causes.
Some women ask about compounded oxytocin nasal spray, used off-label around intimacy and closeness. Evidence is limited and it is not FDA-approved, so your clinician discusses realistic expectations before prescribing. For some couples, counseling or sex therapy makes the biggest difference, and that can be combined with medication.
Each medicine has its own risks, and your clinician reviews your health history, other medicines and alcohol use before prescribing.
Independently licensed U.S. physicians supervise every treatment we offer.

Board-certified in anesthesiology, he reads medications and metabolism with a pharmacologist's eye, which shapes how he doses weight loss and longevity care.

Trained at Columbia and Washington University, he pairs prescriptions with practical habits around food, training and sleep.

An OB-GYN for more than 40 years and a Fellow of ACOG, she leads women's health care, from perimenopause to PCOS.
Still deciding? The first consultation is free and takes about 5–10 minutes.
Book a free consultationTwo FDA-approved options treat low desire: Addyi, a nightly pill, and Vyleesi, an as-needed shot. Compounded PT-141 troches and oxytocin spray are other choices, and changing a medicine that dampens libido sometimes helps most.
As of December 2025, the FDA label covers women younger than 65 with hypoactive sexual desire disorder, which includes many postmenopausal women. Your clinician checks whether it suits you.
It is taken every night and can take several weeks to make a difference. If you haven't noticed any improvement after about eight weeks, it is usually stopped.
Carefully. Wait at least two hours after one or two standard drinks before your bedtime dose, and skip that night's dose if you've had three or more, because alcohol raises the risk of fainting.
You inject it under the skin of the thigh or belly at least 45 minutes before sex, no more than once in 24 hours and no more than eight times a month.
Low-dose vaginal estrogen is a common prescription, often alongside moisturizers and lubricants. If pain persists, pelvic floor therapy or an in-person exam can find other causes.
It's possible, since several antidepressants affect libido and arousal. Don't stop on your own; your clinician can talk through timing, dose changes or alternatives with whoever prescribes it.
Plans start from $99 a month, and the first consultation is free with no insurance needed. Brand-name medicines may cost extra, and your clinician confirms the total first.
Not always. Your clinician may suggest thyroid or hormone tests if your symptoms or history point to them, and explains any lab cost before ordering.
No. Testosterone isn't FDA-approved for women in the U.S., and this service focuses on approved treatments and clearly labeled compounded options. Your clinician can discuss the evidence if you ask.
Yes. Visits are one-on-one by phone or video, medicines ship in plain packaging and your health information is protected under our privacy practices.
Sometimes stress, relationship issues or pain need a different kind of help. Your clinician can recommend counseling, sex therapy or pelvic floor physical therapy, alone or with treatment.
Book a free 5–10 minute phone or video visit. A licensed clinician helps you find the cause and the right treatment, with plans from $99 a month.
Medically reviewed October 2026. This page is general information and not a substitute for advice from your own clinician. Read our editorial policy.